Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1072137 | 0.77 | LMNA (0.36) | HRH1SMN1; SMN2MAPTLIN28ATDP1 | |
| Hydrochloric Acid SCHEMBL1685825 | 0.77 | CYSLTR1 (0.37) | ALDH1A1LMNAMAOAMAOB | |
| SCHEMBL2235411 | 0.75 | HRH1 (0.33) | HRH1SMN1; SMN2MAPTLIN28ATDP1 | |
| Hydrochloric Acid SCHEMBL1685932 | 0.73 | GRIN2D (0.37) | HRH1SMN1; SMN2MAPTALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL819859 | 0.71 | SYK (0.36) | HRH1ALDH1A1LMNAHRH3MAOA | |
| Hydrochloric Acid SCHEMBL5009135 | 0.69 | NPC1 (0.37) | ALDH1A1LMNAHRH3TAAR1ALOX15 | |
| Hydrochloric Acid SCHEMBL5003511 | 0.68 | ALDH1A1 (0.35) | HRH1ALDH1A1MEN1PKMKMT2A | |
| Hydrochloric Acid SCHEMBL27617900 | 0.67 | ALDH1A1 (0.41) | HRH1TDP1ALDH1A1LMNAHRH3 | |
| Hydrochloric Acid SCHEMBL1436915 | 0.64 | HRH3 (0.41) | HRH1SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL27053801 | 0.62 | LMNA (0.60) | HRH1SMN1; SMN2MAPTLIN28ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824888-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2017-01-18 | — | — | EP | disclosed |
| US-7973114-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2011-07-05 | — | — | US | disclosed |
| EP-1572359-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2010-04-28 | — | — | EP | disclosed |
| US-7541473-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2009-06-02 | — | — | US | disclosed |
| US-7507688-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2009-03-24 | — | — | US | disclosed |
| US-20080269445-A1 | Monocyclopentadienyl Complexes | BASELL POLYOLEFINE GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
| EP-1572360-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2008-06-25 | — | — | EP | disclosed |
| US-20080064838-A1 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2008-03-13 | — | — | US | disclosed |
| EP-1824888-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2007-08-29 | — | — | EP | disclosed |
| US-20060166815-A1 | Monocyclopentadienyl complexes | EQUISTAR CHEMICALS, LP | 2006-07-27 | — | — | US | disclosed |
| WO-2006063826-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2006-06-22 | — | — | WO | disclosed |
| US-20060116491-A1 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2006-06-01 | — | — | US | disclosed |
| EP-1572360-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2005-09-14 | — | — | EP | disclosed |
| EP-1572359-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056482-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-07-08 | — | — | WO | disclosed |
| WO-2004056481-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269445-A1 | Monocyclopentadienyl Complexes | PCBP1, COASY, PORCN | HRH1 4483/4885SMN1; SMN2 3981/4885MAPT 1887/4885 |
| US-20080064838-A1 | Monocyclopentadienyl complexes | COASY, PCBP1, ORC3 | HRH1 4141/4885SMN1; SMN2 3926/4885MAPT 1065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.