Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5003514 | 0.79 | ALDH1A1 (0.33) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5003111 | 0.72 | PIP4K2C (0.34) | ALDH1A1NPC1RAB9AKMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL5000186 | 0.70 | ADRA2A (0.36) | ALDH1A1KMT2AMEN1CYP1A2LMNA | |
| Hydrochloric Acid SCHEMBL2235407 | 0.68 | HRH1 (0.36) | ALDH1A1KMT2AMEN1PKMHRH3 | |
| Hydrochloric Acid SCHEMBL5003774 | 0.67 | CHRNA7 (0.36) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL10306737 | 0.63 | PDK2 (0.41) | ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL3084395 | 0.63 | KMT2A (0.33) | ALDH1A1RAB9AKMT2AMEN1HRH3 | |
| Hydrochloric Acid SCHEMBL1436915 | 0.63 | HRH3 (0.41) | ALDH1A1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL17031761 | 0.63 | HRH3 (0.41) | ALDH1A1NPC1RAB9AHRH3CYP1A2 | |
| SCHEMBL3435909 | 0.62 | SYK (0.47) | ALDH1A1NPC1RAB9AHRH3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824888-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2017-01-18 | — | — | EP | disclosed |
| US-20080269445-A1 | Monocyclopentadienyl Complexes | BASELL POLYOLEFINE GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
| EP-1824888-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006063826-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269445-A1 | Monocyclopentadienyl Complexes | PCBP1, COASY, PORCN | ALDH1A1 2394/4885NPC1 2120/4885RAB9A 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.