Sugi Predict

Sugi Predict / Compounds / SCHEMBL2235448

SCHEMBL2235448

SCHEMBL2235448

CCC(CN1C(=O)c2ccccc2C1=O)[C@@H](O)c1cccc(OCC2CCCCC2)c1

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 1/20 0.39
▸ MAOB P27338 1/20 0.39
▸ PRMT5 O14744 1/20 0.39
▸ WDR77 Q9BQA1 1/20 0.39
▸ SIRT2 Q8IXJ6 1/20 0.39
▸ DUT P33316 3/20 0.38
▸ PDK2 Q15119 1/20 0.38
▸ FFAR1 O14842 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ TLR4 O00206 1/20 0.37
▸ TLR2 O60603 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2235433 1.00 MAOA (0.39) MAOAMAOBPRMT5WDR77SIRT2
SCHEMBL2235442 1.00 MAOA (0.39) MAOAMAOBPRMT5WDR77SIRT2
SCHEMBL2209619 0.88 DUT (0.41) MAOAMAOBPRMT5WDR77SIRT2
SCHEMBL4085382 0.88 DUT (0.41) MAOAMAOBPRMT5WDR77SIRT2
SCHEMBL17024422 0.87 DUT (0.42) DUTFFAR1KMT2A
SCHEMBL2205493 0.87 DUT (0.42) DUTFFAR1KMT2A
SCHEMBL2206778 0.85 MAOA (0.39) MAOAMAOBDUTTLR4TLR2
SCHEMBL2206773 0.85 MAOA (0.39) MAOAMAOBDUTTLR4TLR2
SCHEMBL2206779 0.85 MAOA (0.39) MAOAMAOBDUTTLR4TLR2
SCHEMBL20295198 0.85 MAOA (0.39) MAOAMAOBDUTTLR4TLR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 — — US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 — — US disclosed
US-11446261-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2022-09-20 — — US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 — — US disclosed
US-10639286-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2020-05-05 — — US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 — — US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 — — US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 — — US disclosed
EP-3210966-A1 ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Acucela, Inc. (US) 2017-08-30 — — EP disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 — — US disclosed
US-9079825-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-07-14 — — US disclosed
US-8993807-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-31 — — US disclosed
US-8981153-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-17 — — US disclosed
US-8829244-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2014-09-09 — — US disclosed
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA, INC. (US) 2013-08-01 — — US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 — — US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 — — US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 — — US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 — — US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOA 443/4885MAOB 332/4885PRMT5 3741/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-11446261-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885
US-10639286-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER MAOA 421/4885MAOB 318/4885PRMT5 3758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.