Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22364176 | 0.81 | CCNC (0.45) | HDAC1SIRT2CYP11B2CYP11B1CNR2 | |
| SCHEMBL9456168 | 0.80 | PTPN1 (0.55) | SIRT2CYP11B2CYP11B1CNR2PTPN1 | |
| SCHEMBL22186888 | 0.80 | HDAC1 (0.42) | HDAC1SIRT2CYP11B2CYP11B1CDK8 | |
| SCHEMBL30701976 | 0.80 | HDAC1 (0.42) | HDAC1SIRT2CYP11B2CYP11B1CDK8 | |
| SCHEMBL23582210 | 0.79 | BACE1 (0.40) | CYP11B2CYP11B1BACE1CYP4F2CYP4A11 | |
| SCHEMBL23582627 | 0.79 | ROCK2 (0.49) | HDAC1SIRT2CNR2PTPN1SYK | |
| SCHEMBL5033493 | 0.78 | PTPN1 (0.54) | SIRT2PTPN1FFAR1 | |
| SCHEMBL5039697 | 0.78 | PTPN1 (0.54) | SIRT2CYP11B2CYP11B1CNR2PTPN1 | |
| SCHEMBL1067199 | 0.78 | SIRT2 (0.54) | SIRT2CYP11B2CYP11B1PTPN1CYP4F2 | |
| SCHEMBL12087496 | 0.78 | HDAC1 (0.52) | HDAC1SIRT2CYP11B2CYP11B1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759799-B2 | Indazole containing macrocycles and therapeutic uses thereof | SAMUMED, LLC (US) | 2020-09-01 | — | — | US | disclosed |
| US-10759799-B2 | Indazole containing macrocycles and therapeutic uses thereof | SAMUMED, LLC (US) | 2020-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759799-B2 | Indazole containing macrocycles and therapeutic uses thereof | WNT1, WNT3, WNT3A | HDAC1 164/4885SIRT2 892/4885CYP11B2 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.