Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 3/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903650 | 0.82 | ALDH1A1 (0.46) | KDM4ECYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL20954377 | 0.80 | CYP1A2 (0.41) | KDM4ECYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL28687511 | 0.79 | KDM4E (0.49) | KDM4ECYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL3705785 | 0.78 | CYP1A2 (0.44) | KDM4ECYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL16619651 | 0.78 | P2RX7 (0.37) | KDM4EL3MBTL1SMN1; SMN2MAPTHTT | |
| SCHEMBL17986606 | 0.78 | KDM4E (0.49) | KDM4ECYP1A2CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL26850220 | 0.78 | POLB (0.44) | KDM4ECYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL3151323 | 0.76 | HCAR2 (0.56) | CYP1A2CYP3A4CYP2C19HCAR2 | |
| SCHEMBL10682408 | 0.76 | TACR1 (0.38) | KDM4ECYP1A2CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL3515284 | 0.76 | KDM4E (0.45) | KDM4ECYP1A2CYP3A4CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759799-B2 | Indazole containing macrocycles and therapeutic uses thereof | SAMUMED, LLC (US) | 2020-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759799-B2 | Indazole containing macrocycles and therapeutic uses thereof | WNT1, WNT3, WNT3A | KDM4E 3083/4885CYP1A2 1492/4885CYP3A4 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.