Sugi Predict

Sugi Predict / Compounds / Iodide

Iodide

Iodide

SCHEMBL22366402

Cc1cc[n+](C)c(CNC(=O)OC(C)(C)C)c1.[I-]

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4A O75164 1/20 0.42
▸ POLB P06746 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ NAMPT P43490 2/20 0.36
▸ MAPT P10636 4/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ GLS O94925 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ GAA P10253 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ GLA P06280 1/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ HDAC1 Q13547 1/20 0.35
▸ NQO2 P16083 1/20 0.34
▸ CACNA1H O95180 1/20 0.34
▸ CACNA1B Q00975 1/20 0.34
▸ CACNA1C Q13936 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28405232 0.99 KDM4A (0.43) KDM4APOLBL3MBTL1NAMPTMAPT
Iodide SCHEMBL22366521 0.81 KDM4A (0.47) KDM4AL3MBTL1NAMPTATMHDAC1
Iodide SCHEMBL22366399 0.80 MAPT (0.41) KDM4APOLBL3MBTL1NAMPTMAPT
SCHEMBL28405161 0.79 KDM4A (0.48) KDM4AL3MBTL1NAMPTGLSATM
SCHEMBL28405237 0.78 MAPT (0.41) KDM4APOLBL3MBTL1NAMPTMAPT
SCHEMBL10553465 0.76 IDO1 (0.37) KDM4AMAPTKDM4EGAAALDH1A1
SCHEMBL5015072 0.73 NPC1 (0.54) KDM4AL3MBTL1MAPTLMNAGAA
Iodide SCHEMBL482058 0.73 APOBEC3A (0.50) KDM4AL3MBTL1NAMPTMAPTTDP1
SCHEMBL16020311 0.72 KDM4A (0.44) KDM4AL3MBTL1NAMPTHPGD
SCHEMBL8279661 0.71 POLB (0.53) KDM4APOLBNAMPTMAPTGLS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200339567-A1 SUBSTITUTED IMIDAZOPYRIDINE AMIDES AND USE THEREOF BAYER AKTIENGESELLSCHAFT (DE) 2020-10-29 — — US disclosed
WO-2020216669-A1 PHENYL-SUBSTITUTED IMIDAZOPYRIDINE AMIDES AND USE THEREOF BAYER AKTIENGESELLSCHAFT (DE) 2020-10-29 — — WO disclosed
EP-3700903-A1 SUBSTITUTED IMIDAZOPYRIDINE AMIDES AND USE THEREOF Bayer Aktiengesellschaft (DE) 2020-09-02 — — EP disclosed
CN-111225917-A Substituted imidazopyridine amides and uses thereof 拜耳股份公司 2020-06-02 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339567-A1 SUBSTITUTED IMIDAZOPYRIDINE AMIDES AND USE THEREOF GOT2, ABAT, OAT KDM4A 3719/4885POLB 2298/4885L3MBTL1 4278/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.