SCHEMBL22367114

SCHEMBL22367114

COc1ccc(C)c(-c2ccccc2I)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
C1R P00736 1/20 0.45
CYP1A2 P05177 4/20 0.42
CYP2A6 P11509 1/20 0.42
GPR3 P46089 1/20 0.42
ABL1 P00519 1/20 0.41
ABCB1 P08183 1/20 0.41
BCR P11274 1/20 0.41
CYP2C19 P33261 3/20 0.40
CYP2C9 P11712 2/20 0.40
GAA P10253 2/20 0.40
PDK2 Q15119 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HTR7 P34969 2/20 0.39
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
ACHE P22303 1/20 0.38
KDM4E B2RXH2 2/20 0.38
NPC1 O15118 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21480791 0.85 CYP1A2 (0.48) CYP1A2CYP2A6GPR3ABL1ABCB1
SCHEMBL11281941 0.80 HTR7 (0.58) CYP1A2CYP2A6CYP2C19CYP2C9HDAC4
SCHEMBL851675 0.77 ELANE (0.45) C1RCYP1A2CYP2A6PDK2KDM4E
SCHEMBL24017192 0.76 SHMT2 (0.40) CYP1A2CYP2A6CYP2C19CYP2C9CYP11B1
SCHEMBL7121378 0.76 CA1 (0.48) CYP1A2CYP2A6CYP2C19CYP2C9ACHE
SCHEMBL11242972 0.76 BACE1 (0.51) CYP1A2CYP2A6ABL1ABCB1BCR
SCHEMBL4224633 0.76 BACE1 (0.51) CYP1A2CYP2A6ABL1ABCB1BCR
SCHEMBL1723322 0.75 ACHE (0.52) CYP1A2CYP2A6CYP2C19CYP2C9GAA
SCHEMBL25800817 0.75 C1R (0.48) C1RGAANPC1ALDH1A1RAB9A
SCHEMBL3459253 0.74 CA12 (0.46) CYP1A2CYP2A6GAAACHEKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3162822-B1 MONOMER COMPOSITION AND CURABLE COMPOSITION CONTAINING SAME DAICEL CORP (JP) 2020-08-26 EP disclosed