SCHEMBL2236889

SCHEMBL2236889

Cc1ccc2c(c1-c1cc(C(C)(C)C)cc(C(C)(C)C)c1)C=C(Br)C2

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RXRB P28702 4/20 0.33
RXRA P19793 3/20 0.33
HTR1D P28221 1/20 0.33
POLB P06746 1/20 0.33
RXRG P48443 2/20 0.32
S1PR1 P21453 2/20 0.31
S1PR3 Q99500 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2235094 0.88 KIF11 (0.37) RXRBRXRA
SCHEMBL2234405 0.87 TSHR (0.32) MAPT
SCHEMBL4625148 0.85 POLB (0.34) RXRBRXRAHTR1DPOLBRXRG
SCHEMBL2234221 0.82 MEN1 (0.31) MAPT
SCHEMBL2235082 0.82 NPC1 (0.30)
SCHEMBL2235465 0.79
SCHEMBL2235324 0.78
SCHEMBL2235659 0.77 AKT2 (0.31) KDM4EMAPT
SCHEMBL2234463 0.77 KIF11 (0.35)
SCHEMBL2236190 0.77 CYP1A1 (0.34) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2360163-B1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN JAPAN POLYPROPYLENE CORP (JP) 2014-06-25 EP disclosed
US-8461365-B2 Metallocene complex and polymerization method of olefin JAPAN POLYPROPYLENE CORPORATION (JP) 2013-06-11 US disclosed
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN JAPAN POLYPROPYLENE CORPORATION (JP) 2011-09-22 US disclosed
EP-2360163-A1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN Japan Polypropylene Corporation (JP) 2011-08-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN ALOX12, ALOX15, ALOX15B RXRB 4039/4885RXRA 3592/4885HTR1D 2498/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.