SCHEMBL223699

SCHEMBL223699

Nc1c(N)c(-c2ccccc2)c(-c2ccccc2)c(O)c1O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 2/20 0.41
PDE4B Q07343 2/20 0.41
PDE4C Q08493 2/20 0.41
PDE4D Q08499 2/20 0.41
HDAC4 P56524 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
ALDH1A1 P00352 5/20 0.38
HSD17B10 Q99714 4/20 0.38
MAPT P10636 3/20 0.38
LMNA P02545 3/20 0.38
HPGD P15428 3/20 0.38
HTT P42858 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
HSP90AA1 P07900 1/20 0.38
GAA P10253 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6678522 0.87 PDE4A (0.38) PDE4APDE4BPDE4CPDE4DHDAC4
SCHEMBL2207002 0.87 PDE4A (0.38) PDE4APDE4BPDE4CPDE4DHDAC4
SCHEMBL21248552 0.86 PDE4A (0.43) PDE4APDE4BPDE4CPDE4DHDAC4
SCHEMBL6678528 0.82 PDE4B (0.35) PDE4APDE4BPDE4CPDE4DHDAC4
SCHEMBL8644874 0.80 PDE4A (0.50) PDE4APDE4BPDE4CPDE4DHDAC4
SCHEMBL2069055 0.80 HSD17B10 (0.48) ALDH1A1HSD17B10MAPTLMNAHPGD
SCHEMBL19253312 0.78 HDAC4 (0.52) PDE4APDE4BPDE4CPDE4DHDAC4
SCHEMBL19253225 0.78 HSD17B10 (0.46) ALDH1A1HSD17B10MAPTLMNAHPGD
SCHEMBL20837496 0.77 ALDH1A1 (0.50) ALDH1A1HSD17B10MAPTLMNAHPGD
SCHEMBL675595 0.77 ALDH1A1 (0.50) ALDH1A1HSD17B10MAPTLMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8883384-B2 Binderless overcoat layer XEROX CORPORATION (US) 2014-11-11 US disclosed
US-8481237-B2 Photoconductor overcoat layer XEROX CORPORATION (US) 2013-07-09 US disclosed
US-20120189949-A1 PHOTOCONDUCTOR OVERCOAT LAYER XEROX CORPORATION (US) 2012-07-26 US disclosed
EP-1998224-B1 Photoconductors and coating compositions XEROX CORP (US) 2012-05-23 EP disclosed
US-8088542-B2 Overcoat containing titanocene photoconductors XEROX CORPORATION (US) 2012-01-03 US disclosed
EP-1967906-B1 Polyhydroxy Siloxane imaging members XEROX CORP (US) 2011-04-27 EP disclosed
US-7932006-B2 Photoconductors XEROX CORPORATION (US) 2011-04-26 US disclosed
US-7855039-B2 Photoconductors containing ketal overcoats XEROX CORPORATION (US) 2010-12-21 US disclosed
US-7799495-B2 Metal oxide overcoated photoconductors XEROX CORPORATION (US) 2010-09-21 US disclosed
US-7799497-B2 Silanol containing overcoated photoconductors XEROX CORPORATION (US) 2010-09-21 US disclosed
US-20080299472-A1 Photoconductors XEROX CORPORATION 2008-12-04 US disclosed
EP-1998224-A1 Photoconductors and coating compositions Xerox Corporation (US) 2008-12-03 EP disclosed
EP-1967906-A1 Polyhydroxy Siloxane Photoconductors Xerox Corporation (US) 2008-09-10 EP disclosed
US-20080193866-A1 Polyhydroxy siloxane photoconductors XEROX CORPORATION 2008-08-14 US disclosed
US-20080107983-A1 Overcoated photoconductors with thiophosphate containing photogenerating layer XEROX CORPORATION 2008-05-08 US disclosed
US-20080107984-A1 Overcoated photoconductors with thiophosphate containing charge transport layers XEROX CORPORATION 2008-05-08 US disclosed
US-20080107985-A1 Silanol containing overcoated photoconductors XEROX CORPORATION 2008-05-08 US disclosed
US-20080107979-A1 Silanol containing charge transport overcoated photoconductors XEROX CORPORATION 2008-05-08 US disclosed
US-20080070137-A1 LIQUID INK RESISTANT PHOTORECEPTOR XEROX CORPORATION 2008-03-20 US disclosed
US-20070134573-A1 PHOTORECEPTOR WITH OVERCOAT LAYER XEROX CORPORATION (US) 2007-06-14 US disclosed