Sugi Predict

Sugi Predict / Compounds / SCHEMBL22370720

SCHEMBL22370720

SCHEMBL22370720

COC(=O)[C@H](COC[C@H]1CCCCN1C(=O)O)NC(=O)OCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.53
▸ L3MBTL1 Q9Y468 1/20 0.53
▸ PREP P48147 2/20 0.47
▸ ACE P12821 1/20 0.47
▸ ABHD6 Q9BV23 1/20 0.47
▸ DAGLA Q9Y4D2 1/20 0.47
▸ FKBP1A P62942 1/20 0.47
▸ CTSK P43235 11/20 0.46
▸ CTSL P07711 6/20 0.45
▸ CTSS P25774 4/20 0.45
▸ KYNU Q16719 1/20 0.45
▸ CTSB P07858 2/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22370724 1.00 ATM (0.53) ATML3MBTL1PREPACEABHD6
SCHEMBL22370727 1.00 ATM (0.53) ATML3MBTL1PREPACEABHD6
SCHEMBL22370277 0.97 PREP (0.50) ATML3MBTL1PREPACECTSK
SCHEMBL22370271 0.97 PREP (0.50) ATML3MBTL1PREPACECTSK
SCHEMBL20897280 0.97 PREP (0.50) ATML3MBTL1PREPACECTSK
SCHEMBL19207678 0.97 PREP (0.50) ATML3MBTL1PREPACECTSK
SCHEMBL29253240 0.89 ATM (0.49) ATML3MBTL1PREPACEABHD6
SCHEMBL28456203 0.89 ATM (0.49) ATML3MBTL1PREPACEABHD6
SCHEMBL28456201 0.89 ATM (0.49) ATML3MBTL1PREPACEABHD6
SCHEMBL24300050 0.86 CTSK (0.46) ATML3MBTL1PREPACECTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240199655-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2024-06-20 — — US disclosed
CN-111491938-B Immunoproteasome inhibitors 普林斯匹亚生物制药公司 2024-05-24 — — CN disclosed
US-11827656-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2023-11-28 — — US disclosed
US-20220073538-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2022-03-10 — — US disclosed
US-11225493-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2022-01-18 — — US disclosed
EP-3710458-A1 IMMUNOPROTEASOME INHIBITORS Principia Biopharma Inc. (US) 2020-09-23 — — EP disclosed
US-20200277312-A1 IMMUNOPROTEASOME INHIBITORS PRINCIPIA BIOPHARMA INC. 2020-09-03 — — US disclosed
CN-111491938-A Immunoproteasome inhibitors 普林斯匹亚生物制药公司 2020-08-04 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827656-B2 Immunoproteasome inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885PREP 80/4885
US-20240199655-A1 Immunoproteasome Inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885PREP 80/4885
US-20200277312-A1 IMMUNOPROTEASOME INHIBITORS PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885PREP 80/4885
US-11225493-B2 Immunoproteasome inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885PREP 80/4885
US-20220073538-A1 Immunoproteasome Inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885PREP 80/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.