Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1299290 | 0.98 | MAPT (0.53) | MAPTNPC1CACNA1CCACNA1FCACNA1D | |
| SCHEMBL20640075 | 0.84 | ALDH1A1 (0.45) | MAPTNPC1CACNA1CCACNA1FCACNA1D | |
| SCHEMBL12393146 | 0.82 | AR (0.55) | MAPTNPC1ADORA3ARSMN1; SMN2 | |
| SCHEMBL1160193 | 0.81 | MEN1 (0.50) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2237150 | 0.79 | BAZ2B (0.39) | MAPTNPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6819783 | 0.79 | MAPT (0.39) | MAPTNPC1CACNA1CCACNA1FCACNA1D | |
| SCHEMBL6805379 | 0.79 | AR (0.39) | MAPTNPC1CACNA1CCACNA1FCACNA1D | |
| SCHEMBL1185764 | 0.77 | NR3C2 (0.42) | MAPTNPC1SMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL2148753 | 0.75 | GABRP (0.51) | MAPTNPC1SMN1; SMN2GABRPGABRD | |
| SCHEMBL6180951 | 0.75 | NPC1 (0.43) | MAPTNPC1CACNA1CCACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |