SCHEMBL1160193

SCHEMBL1160193

COC(=O)c1cc([N+](=O)[O-])c[nH]1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
BAZ2B Q9UIF8 1/20 0.49
BAZ2A Q9UIF9 1/20 0.49
ALDH1A1 P00352 6/20 0.45
POLB P06746 1/20 0.43
CSF1R P07333 1/20 0.42
GAA P10253 2/20 0.42
LMNA P02545 1/20 0.42
GLA P06280 1/20 0.42
HTT P42858 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPT P10636 1/20 0.41
SLC6A3 Q01959 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1185764 0.82 NR3C2 (0.42) MEN1KMT2AALDH1A1CSF1RGAA
SCHEMBL1299290 0.82 MAPT (0.53) MEN1KMT2APOLBLMNASMN1; SMN2
SCHEMBL27721951 0.82 MEN1 (0.53) MEN1KMT2ABAZ2BBAZ2AALDH1A1
SCHEMBL2237150 0.82 BAZ2B (0.39) MEN1KMT2ABAZ2BBAZ2AALDH1A1
SCHEMBL18414587 0.81 ALDH1A1 (0.41) MEN1KMT2AALDH1A1CSF1RLMNA
Ammonia Solution, Strong SCHEMBL2237158 0.81 MAPT (0.52) MEN1KMT2APOLBLMNASMN1; SMN2
SCHEMBL29191080 0.79 ALDH1A1 (0.64) MEN1KMT2ABAZ2BBAZ2AALDH1A1
SCHEMBL1663200 0.79 CREBBP (0.54) MEN1KMT2AALDH1A1CSF1RLMNA
SCHEMBL3348546 0.79 ALDH1A1 (0.50) MEN1KMT2AALDH1A1POLBGAA
SCHEMBL1073975 0.78 ALDH1A1 (0.47) MEN1KMT2AALDH1A1POLBCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024182778-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-09-06 WO disclosed
WO-2023138412-A1 FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS INSILICO MEDICINE IP LIMITED (CN) 2023-07-27 WO disclosed
US-20220308043-A1 FLUORESCENT PROBES FOR IDENTIFICATION AND QUANTIFICATION OF HEPATIC TRANSPORTERS IN VITRO AND IN VIVO CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2022-09-29 US disclosed
CN-108026105-B TGF-beta receptor antagonists 百时美施贵宝公司 2020-10-16 CN disclosed
US-10336761-B2 TGFβ receptor antagonist BRISTOL-MYERS SQUIBB COMPANY (US) 2019-07-02 US disclosed
US-10336761-B2 TGFβ receptor antagonist BRISTOL-MYERS SQUIBB COMPANY (US) 2019-07-02 US disclosed
US-20180215761-A1 TGF BETA RECEPTOR ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2018-08-02 US disclosed
US-20180215761-A1 TGF BETA RECEPTOR ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2018-08-02 US disclosed
US-20180215761-A1 TGF BETA RECEPTOR ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2018-08-02 US disclosed
EP-3325484-A1 TGF BETA RECEPTOR ANTAGONISTS Bristol-Myers Squibb Company (US) 2018-05-30 EP disclosed
US-6051243-A USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-04-18 US disclosed
EP-0991417-A1 COMPLEX FORMATION BETWEEN DSDNA AND OLIGOMER OF HETEROCYCLES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2000-04-12 EP disclosed
EP-0986539-A1 DNA-BINDING PYRROLE AND IMIDAZOLE POLYAMIDE DERIVATIVES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2000-03-22 EP disclosed
US-5998140-A COMPLEXES OF CELL WITH OLIGOMER THE SCRIPPS RESEARCH INSTITUTE (US) 1999-12-07 US disclosed
EP-0885189-A2 METHOD FOR THE SYNTHESIS OF POLY-PYRROLE AND POLY-IMIDAZOLE CARBOXAMIDES ON A SOLID SUPPORT CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1998-12-23 EP disclosed
WO-1998050058-A1 COMPLEX FORMATION BETWEEN DSDNA AND OLIGOMER OF HETEROCYCLES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1998-11-12 WO disclosed
WO-1998050582-A1 COMPLEX FORMATION BETWEEN dsDNA AND OLIGOMER OF HETEROCYCLES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1998-11-12 WO disclosed
WO-1998049142-A1 DNA-BINDING PYRROLE AND IMIDAZOLE POLYAMIDE DERIVATIVES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1998-11-05 WO disclosed
US-5709867-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-01-20 US disclosed
WO-1997030975-A2 METHOD FOR THE SYNTHESIS OF POLY-PYRROLE AND POLY-IMIDAZOLE CARBOXAMIDES ON A SOLID SUPPORT CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 1997-08-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336761-B2 TGFβ receptor antagonist TGFBR2, TGFBR1, SMAD2 MEN1 3092/4885KMT2A 2468/4885BAZ2B 1746/4885
US-20180215761-A1 TGF BETA RECEPTOR ANTAGONISTS TGFBR2, TGFBR1, TGFB2 MEN1 2799/4885KMT2A 2698/4885BAZ2B 2000/4885
US-20220308043-A1 FLUORESCENT PROBES FOR IDENTIFICATION AND QUANTIFICATION OF HEPATIC TRANSPORTERS IN VITRO AND IN VIVO ABCB11, SLC10A1, SLC10A2 MEN1 3014/4885KMT2A 4811/4885BAZ2B 2959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.