SCHEMBL22372172

SCHEMBL22372172

CON(C)C(=O)c1ncn[nH]1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.44
CYP2C19 P33261 3/20 0.44
CYP2C9 P11712 2/20 0.44
L3MBTL1 Q9Y468 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
HPGD P15428 2/20 0.42
TP53 P04637 1/20 0.42
HTT P42858 2/20 0.40
TSHR P16473 1/20 0.40
APOBEC3A P31941 2/20 0.37
APOBEC3G Q9HC16 2/20 0.37
CYP3A4 P08684 2/20 0.37
SMYD3 Q9H7B4 1/20 0.36
LMNA P02545 2/20 0.35
KDM4E B2RXH2 1/20 0.35
USP2 O75604 1/20 0.35
ALOX15 P16050 1/20 0.35
ALPL P05186 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22372303 0.83 CYP1A2 (0.39) CYP1A2CYP2C19CYP2C9L3MBTL1SMN1; SMN2
SCHEMBL21632736 0.81 L3MBTL1 (0.42) CYP1A2CYP2C19CYP2C9L3MBTL1SMN1; SMN2
SCHEMBL22372238 0.75 L3MBTL1 (0.40) CYP1A2CYP2C19CYP2C9L3MBTL1SMN1; SMN2
SCHEMBL1430713 0.73
SCHEMBL22372221 0.71 NPC1 (0.44) SMN1; SMN2HTTKDM4EKMT2AMLYCD
SCHEMBL22372289 0.70 KDM4E (0.44) CYP1A2CYP2C19CYP2C9L3MBTL1SMN1; SMN2
SCHEMBL22372080 0.69 MLYCD (0.32) MLYCD
SCHEMBL22372244 0.68 HCAR2 (0.50) CYP1A2L3MBTL1SMN1; SMN2TP53TSHR
SCHEMBL1947309 0.68
SCHEMBL20570053 0.67 TRPM8 (0.34) MEN1KMT2AMLYCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12264138-B2 Process for the preparation of microbiocidal oxadiazole derivatives SYNGENTA CROP PROTECTION AG (CH) 2025-04-01 US disclosed
US-20220194907-A1 PROCESS FOR THE PREPARATION OF MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2022-06-23 US disclosed
US-11358957-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2022-06-14 US disclosed
US-20200277287-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-09-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12264138-B2 Process for the preparation of microbiocidal oxadiazole derivatives CYP51A1, MPO, NOX5 CYP1A2 30/4885CYP2C19 20/4885CYP2C9 29/4885
US-20200277287-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES PRF1, NOX1, ARG2 CYP1A2 172/4885CYP2C19 331/4885CYP2C9 317/4885
US-11358957-B2 Microbiocidal oxadiazole derivatives PRF1, NOX1, ARG2 CYP1A2 172/4885CYP2C19 331/4885CYP2C9 317/4885
US-20220194907-A1 PROCESS FOR THE PREPARATION OF MICROBIOCIDAL OXADIAZOLE DERIVATIVES CYP51A1, MPO, NOX5 CYP1A2 30/4885CYP2C19 20/4885CYP2C9 29/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.