Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.41 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.41 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.41 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.41 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22167284 | 0.84 | MME (0.36) | PPARGPPARAEPHX2RAB9A | |
| SCHEMBL22384241 | 0.84 | NR1H4 (0.56) | PPARGPPARAPPARDEPHX2NR1H4 | |
| SCHEMBL15018822 | 0.83 | PTPN1 (0.47) | — | |
| SCHEMBL15018825 | 0.83 | PTPN1 (0.47) | — | |
| SCHEMBL29129082 | 0.81 | RAB9A (0.63) | PPARGPPARAPPARDEPHX2NR1H4 | |
| SCHEMBL19517703 | 0.79 | MMEL1 (0.50) | EPHX2NR1H4 | |
| SCHEMBL16294791 | 0.78 | CTSB (0.45) | — | |
| SCHEMBL16294368 | 0.77 | GCGR (0.52) | EPHX2NR1H4ADCY6ADCY3ADCY9 | |
| SCHEMBL16294369 | 0.77 | GCGR (0.52) | EPHX2NR1H4ADCY6ADCY3ADCY9 | |
| SCHEMBL28541531 | 0.77 | L3MBTL1 (0.40) | EPHX2NR1H4HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230276-B1 | GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-09-02 | — | — | EP | disclosed |