SCHEMBL2238653

SCHEMBL2238653

FC(F)(F)c1ccc(-n2cccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
PKM P14618 1/20 0.52
TSHR P16473 1/20 0.46
VHL P40337 1/20 0.45
ELOC Q15369 1/20 0.45
ELOB Q15370 1/20 0.45
KDM4E B2RXH2 1/20 0.45
GAA P10253 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
KIF11 P52732 3/20 0.44
AOC2 O75106 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
CYP1A2 P05177 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
TRPV1 Q8NER1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10296074 0.76 GAA (0.50) ALDH1A1TSHRVHLELOCELOB
SCHEMBL709619 0.73 LMNA (0.58) ALDH1A1TSHRMEN1CYP1A2MAPT
SCHEMBL5445153 0.73 TDP1 (0.35) ALDH1A1PKMTSHRKIF11TRPV1
SCHEMBL63468 0.72 ALDH1A1 (0.67) ALDH1A1TSHRKIF11CES2CES1
SCHEMBL2239811 0.72 ALDH1A1 (0.56) ALDH1A1PKMVHLELOCELOB
SCHEMBL4792070 0.71 CA12 (0.49) ALDH1A1TSHRKIF11TRPV1TDP1
SCHEMBL2615405 0.70 TDP1 (0.40) ALDH1A1TSHRL3MBTL1KIF11CYP1A2
SCHEMBL18770799 0.70 ALDH1A1 (0.50) ALDH1A1PKMTSHRL3MBTL1KIF11
SCHEMBL29880724 0.70 ALDH1A1 (0.50) ALDH1A1PKMTSHRL3MBTL1KIF11
SCHEMBL5369751 0.69 ALDH1A1 (0.41) ALDH1A1PKMMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115948751-A Ring-opening dihydroalkoxylation reaction method of electrocatalytic N-aryl maleimide and alcohol 广西师范大学 2023-04-11 CN claimed
CN-115948751-A Ring-opening dihydroalkoxylation reaction method of electrocatalytic N-aryl maleimide and alcohol 广西师范大学 2023-04-11 CN disclosed
US-20180215952-A1 POLISHING COMPOSITION FUJIMI INCORPORATED (JP) 2018-08-02 US disclosed
US-20130225776-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2013-08-29 US disclosed
US-20130225776-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2013-08-29 US disclosed
US-20130225776-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2013-08-29 US disclosed
US-20120208978-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2012-08-16 US disclosed
US-20120208978-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2012-08-16 US disclosed
US-20120208978-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2012-08-16 US disclosed
CN-102333772-A Antiviral compounds ABBOTT LAB 2012-01-25 CN disclosed
US-20110190461-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2011-08-04 US disclosed
US-20110190461-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2011-08-04 US disclosed
US-20110190461-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER NAGASE CHEMTEX CORPORATION (JP) 2011-08-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190461-A1 NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER PAH, AHR, KCNH3 ALDH1A1 1712/4885PKM 1559/4885TSHR 565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.