Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | YAP1 | P46937 | 3/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241389 | 0.90 | PDE4B (0.51) | PDE4BYAP1TACR1L3MBTL1JAK2 | |
| SCHEMBL2242155 | 0.90 | PDE4B (0.51) | PDE4BYAP1TACR1L3MBTL1JAK2 | |
| SCHEMBL2243513 | 0.88 | KCNH2 (0.47) | PDE4BTACR1HSD11B1KCNH2ALDH1A1 | |
| SCHEMBL27801739 | 0.85 | KCNH2 (0.43) | PDE4BTACR1BCL9CTNNB1KCNH2 | |
| SCHEMBL2239880 | 0.84 | TACR1 (0.54) | PDE4BYAP1TACR1PRMT5JAK2 | |
| SCHEMBL19893583 | 0.84 | PDE4B (0.52) | PDE4BTACR1L3MBTL1JAK2JAK1 | |
| SCHEMBL19893582 | 0.84 | PDE4B (0.52) | PDE4BTACR1L3MBTL1JAK2JAK1 | |
| SCHEMBL19893581 | 0.84 | PDE4B (0.52) | PDE4BTACR1L3MBTL1JAK2JAK1 | |
| SCHEMBL30889444 | 0.83 | PDE4B (0.58) | PDE4BTACR1L3MBTL1BCL9CTNNB1 | |
| SCHEMBL29492127 | 0.82 | HSD11B1 (0.50) | PDE4BL3MBTL1JAK2JAK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO. | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVE | REN, AGTR1, AGTR2 | PDE4B 1236/4885YAP1 595/4885TACR1 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.