Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14054267 | 1.00 | CHRNB2 (0.46) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2240742 | 1.00 | CHRNB2 (0.46) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2240739 | 1.00 | CHRNB2 (0.46) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14053649 | 1.00 | CHRNB2 (0.46) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14053851 | 0.95 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14054537 | 0.95 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14054540 | 0.95 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14053857 | 0.95 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12355495 | 0.95 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17870930 | 0.91 | RIPK1 (0.47) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536687-A2 | PROCESS FOR SYNTHESIS OF 2-SUBSTITUTED PYRROLIDINES AND PIPERADINES | Novartis AG (CH) | 2012-12-26 | — | — | EP | disclosed |
| US-20120302756-A1 | PROCESS FOR SYNTHESIS OF 2-SUBSTITUTED PYRROLIDINES AND PIPERADINES | NOVARTIS AG (CH) | 2012-11-29 | — | — | US | disclosed |
| WO-2011103263-A2 | PROCESS FOR SYNTHESIS OF 2-SUBSTITUTED PYRROLIDINES AND PIPERADINES | NOVARTIS AG (CH) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302756-A1 | PROCESS FOR SYNTHESIS OF 2-SUBSTITUTED PYRROLIDINES AND PIPERADINES | DHPS, ALDH18A1, QDPR | CHRNB2 3663/4885CHRNA7 3951/4885CHRNA4 3062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.