Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.60 |
| ▸ | NSD2 | O96028 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240872 | 0.80 | PPIA (0.61) | HPGDALDH1A1NSD2KDM4EKMT2A | |
| SCHEMBL14454229 | 0.78 | TSHR (0.62) | HPGDALDH1A1NSD2KDM4EKMT2A | |
| SCHEMBL22720198 | 0.78 | TSHR (0.55) | HPGDTP53ALDH1A1GAAKDM4E | |
| SCHEMBL27604453 | 0.78 | HPGD (1.00) | HPGDTP53GLAALDH1A1GAA | |
| SCHEMBL28729066 | 0.78 | HPGD (0.68) | HPGDTP53GLAALDH1A1NSD2 | |
| SCHEMBL1558671 | 0.77 | CA12 (0.52) | HPGDALDH1A1GAATAAR1KDM4E | |
| SCHEMBL1558070 | 0.77 | CA12 (0.52) | HPGDALDH1A1GAATAAR1KDM4E | |
| SCHEMBL31740895 | 0.77 | ALDH1A1 (0.58) | HPGDTP53GLAALDH1A1GAA | |
| SCHEMBL13175594 | 0.77 | L3MBTL1 (0.68) | HPGDTP53GLAALDH1A1USP2 | |
| SCHEMBL3185330 | 0.76 | HPGD (0.78) | HPGDTP53GLAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458141-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-10-04 | — | — | US | disclosed |
| US-9458141-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-10-04 | — | — | US | disclosed |
| US-9458141-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-10-04 | — | — | US | disclosed |
| US-9296729-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-03-29 | — | — | US | disclosed |
| US-9296729-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-03-29 | — | — | US | disclosed |
| US-9296729-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-03-29 | — | — | US | disclosed |
| US-20160024023-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF | 2016-01-28 | — | — | US | disclosed |
| US-20160024023-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF | 2016-01-28 | — | — | US | disclosed |
| US-20160024023-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF | 2016-01-28 | — | — | US | disclosed |
| US-9187457-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-11-17 | — | — | US | disclosed |
| US-8741259-B2 | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2014-06-03 | — | — | US | disclosed |
| US-20130251631-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2013-09-26 | — | — | US | disclosed |
| US-20130251631-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2013-09-26 | — | — | US | disclosed |
| US-20130251631-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2013-09-26 | — | — | US | disclosed |
| EP-2358684-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services (US) | 2011-08-24 | — | — | EP | disclosed |
| US-20110195018-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2011-08-11 | — | — | US | disclosed |
| US-20110195018-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2011-08-11 | — | — | US | disclosed |
| US-20110195018-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2011-08-11 | — | — | US | disclosed |
| WO-2010047674-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010047674-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024023-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | TSHR, THRA, TRHR | HPGD 976/4885TP53 917/4885GLA 2875/4885 |
| US-20110195018-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | TSHR, THRA, TRHR | HPGD 976/4885TP53 917/4885GLA 2875/4885 |
| US-20130251631-A1 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS | TSHR, THRA, TRHR | HPGD 976/4885TP53 917/4885GLA 2875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.