Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15837682 | 0.87 | RAB9A (0.39) | RAB9AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL17300415 | 0.85 | NPC1 (0.37) | RAB9AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL15837555 | 0.84 | NPC1 (0.44) | RAB9AALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL22417579 | 0.73 | DRD2 (0.40) | RAB9AALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL15838002 | 0.72 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL22417691 | 0.72 | ITGB1 (0.33) | RAB9AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL2401291 | 0.71 | L3MBTL1 (0.47) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL17300434 | 0.70 | NPC1 (0.40) | KMT2ANPC1 | |
| SCHEMBL15837601 | 0.69 | NPC1 (0.46) | KMT2ANPC1 | |
| SCHEMBL15837562 | 0.69 | POLB (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935281-B1 | SPIROISOXAZOLINE COMPOUNDS HAVING AN ACTIVITY POTENTIATING THE ACTIVITY OF AN ANTIBIOTIC | UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 (FR) | 2020-09-09 | — | — | EP | disclosed |