Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22417656 | 0.87 | RAB9A (0.41) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17300415 | 0.84 | NPC1 (0.37) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15837555 | 0.84 | NPC1 (0.44) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15837562 | 0.83 | POLB (0.42) | MEN1KMT2A | |
| SCHEMBL22417691 | 0.81 | ITGB1 (0.33) | RAB9AKDM4EALDH1A1NPC1PKM | |
| SCHEMBL15838589 | 0.80 | NPC1 (0.38) | RAB9AALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL15837715 | 0.80 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL15837568 | 0.80 | CRBN (0.42) | RAB9AALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL15838036 | 0.80 | NAMPT (0.37) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15837719 | 0.79 | FKBP1A (0.41) | ALDH1A1SMN1; SMN2MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935281-B1 | SPIROISOXAZOLINE COMPOUNDS HAVING AN ACTIVITY POTENTIATING THE ACTIVITY OF AN ANTIBIOTIC | UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 (FR) | 2020-09-09 | — | — | EP | disclosed |
| US-10174050-B2 | Spiroisoxazoline compounds having an activity potentiating the activity of an antibiotic | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2019-01-08 | — | — | US | disclosed |
| US-20150344498-A1 | Spiroisoxazoline Compounds Having an Activity Potentiating the Activity of an Antibiotic | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2015-12-03 | — | — | US | disclosed |
| US-20150344498-A1 | Spiroisoxazoline Compounds Having an Activity Potentiating the Activity of an Antibiotic | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2015-12-03 | — | — | US | disclosed |
| WO-2014096369-A1 | SPIROISOXAZOLINE COMPOUNDS HAVING AN ACTIVITY POTENTIATING THE ACTIVITY OF AN ANTIBIOTIC | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344498-A1 | Spiroisoxazoline Compounds Having an Activity Potentiating the Activity of an Antibiotic | NPPA, CFTR, TCF7 | RAB9A 1044/4885GBA1 610/4885KDM4E 4533/4885 |
| US-10174050-B2 | Spiroisoxazoline compounds having an activity potentiating the activity of an antibiotic | NPPA, CFTR, TCF7 | RAB9A 1044/4885GBA1 610/4885KDM4E 4533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.