Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843046 | 0.81 | ALDH1A1 (0.73) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL5181762 | 0.81 | ALDH1A1 (0.58) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL1238556 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL7122089 | 0.70 | ALDH1A1 (0.48) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL11693290 | 0.69 | NPC1 (0.71) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL6894434 | 0.68 | KDM4E (0.48) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL7194777 | 0.68 | EPHX2 (0.53) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL7193928 | 0.68 | EPHX2 (0.53) | ALDH1A1GAATDP1EPHX2NPC1 | |
| SCHEMBL5180936 | 0.68 | ALDH1A1 (0.58) | ALDH1A1GAATDP1NPC1RAB9A | |
| SCHEMBL11695743 | 0.68 | NPC1 (0.74) | ALDH1A1GAATDP1EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778011-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OF UBIQUITIN CONJUGATING DISORDERS | Hygeia Biological Systems (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020681-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OF UBIQUITIN CONJUGATING DISORDERS | HYGEIA BIOLOGICAL SYSTEMS (US) | 2006-02-23 | — | — | WO | claimed |
| US-20060035890-A1 | Compounds and methods for the treatment of ubiquitin conjugating disorders | AMIT BANERJEE | 2006-02-16 | — | — | US | claimed |
| US-8541593-B2 | Process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8536345-B2 | Process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8003572-B2 | Method for the treatment of a ubiquitin conjugating disorder | Banerjee, Amit (US) | 2011-08-23 | — | — | US | disclosed |
| US-20110160463-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. | 2011-06-30 | — | — | US | disclosed |
| US-20100280255-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100280255-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2010-11-04 | — | — | US | disclosed |
| WO-2010008729-A2 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2009002445-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| US-20070191488-A1 | Method for the treatment of a ubiquitin conjugating disorder | BANERJEE AMIT | 2007-08-16 | — | — | US | disclosed |
| EP-1778011-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OF UBIQUITIN CONJUGATING DISORDERS | Hygeia Biological Systems (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020681-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OF UBIQUITIN CONJUGATING DISORDERS | HYGEIA BIOLOGICAL SYSTEMS (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20060035890-A1 | Compounds and methods for the treatment of ubiquitin conjugating disorders | AMIT BANERJEE | 2006-02-16 | — | — | US | disclosed |
| US-20050239853-A1 | New compounds | BIOVITRUM AB (SE) | 2005-10-27 | — | — | US | disclosed |
| WO-2005075471-A2 | THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | BIOVITRUM AB (SE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239853-A1 | New compounds | HSD11B1, CYP11B1, HSD3B1 | ALDH1A1 67/4885GAA 522/4885TDP1 804/4885 |
| US-20100280255-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 66/4885GAA 1855/4885TDP1 376/4885 |
| US-20110160463-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 69/4885GAA 1708/4885TDP1 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.