Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 2/20 | 0.30 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31386148 | 0.77 | HTR6 (0.49) | HTR6HTR1AHTR7GPR84FFAR1 | |
| SCHEMBL25613921 | 0.75 | CYP2A6 (0.50) | GPR84FFAR1HTR2ACYP2A6 | |
| SCHEMBL1470845 | 0.73 | HTR6 (0.49) | HTR6HTR1AHTR7GPR84FFAR1 | |
| SCHEMBL16522855 | 0.71 | GPR84 (0.53) | HTR6HTR1AHTR7GPR84FFAR1 | |
| SCHEMBL25075601 | 0.70 | GPR84 (0.40) | HTR6HTR7GPR84FFAR1HTR2A | |
| SCHEMBL24144882 | 0.70 | GPR84 (0.47) | HTR6HTR1AHTR7GPR84FFAR1 | |
| SCHEMBL29955572 | 0.69 | CYP2A6 (0.60) | HTR6HTR1AHTR7GPR84CYP2A6 | |
| SCHEMBL25075605 | 0.69 | GPR84 (0.36) | HTR6GPR84HTR2A | |
| SCHEMBL22483859 | 0.69 | KDM1A (0.35) | — | |
| SCHEMBL827309 | 0.68 | HTR2C (0.46) | GPR84FFAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111448190-B | Substituted indole compounds | 百时美施贵宝公司 | 2023-09-26 | — | — | CN | disclosed |
| US-11739098-B2 | Substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-29 | — | — | US | disclosed |
| EP-3710440-B1 | SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-04-05 | — | — | EP | disclosed |
| US-20230098244-A1 | SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-03-30 | — | — | US | disclosed |
| US-20210253593-A1 | SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-08-19 | — | — | US | disclosed |
| EP-3710440-A1 | SUBSTITUTED INDOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2020-09-23 | — | — | EP | disclosed |
| CN-111448190-A | Substituted indole compounds | 百时美施贵宝公司 | 2020-07-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230098244-A1 | SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, HTR7 | HTR6 44/4885HTR1A 46/4885HTR7 3/4885 |
| US-20210253593-A1 | SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, HTR7 | HTR6 44/4885HTR1A 46/4885HTR7 3/4885 |
| US-11739098-B2 | Substituted indole compounds | TLR7, TLR1, HTR7 | HTR6 44/4885HTR1A 46/4885HTR7 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.