Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
| ▸ | ACACA | Q13085 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439238 | 0.85 | SMN1; SMN2 (0.36) | KMT2ALMNASMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL29060426 | 0.80 | LMNA (0.35) | KMT2ALMNASTK17BSTK17AHSP90AA1 | |
| SCHEMBL18167877 | 0.75 | STK17B (0.37) | KMT2ALMNASTK17BSTK17AHSP90AA1 | |
| SCHEMBL22509297 | 0.74 | PAX8 (0.39) | KMT2ALMNAALDH1A1STK17BSTK17A | |
| SCHEMBL22502038 | 0.72 | STK17B (0.35) | KMT2ALMNASTK17BSTK17AHSP90AA1 | |
| SCHEMBL28561925 | 0.72 | SSTR4 (0.37) | KMT2ALMNAALDH1A1MAPK1 | |
| SCHEMBL8819965 | 0.71 | SYK (0.35) | KMT2ALMNASTK17BSTK17AHSP90AA1 | |
| SCHEMBL28960930 | 0.71 | KMT2A (0.42) | KMT2ALMNASTK17BSTK17AHSP90AA1 | |
| SCHEMBL4555591 | 0.70 | TAS1R3 (0.39) | KMT2ALMNASMN1; SMN2ALDH1A1STK17B | |
| SCHEMBL1053992 | 0.69 | HSP90AA1 (0.36) | KMT2ALMNASTK17BSTK17AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | KMT2A 139/4885LMNA 2517/4885SMN1; SMN2 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.