Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453464 | 0.84 | POLB (0.58) | EPHX2ALDH1A1LMNACA1CA2 | |
| SCHEMBL22452967 | 0.82 | NPC1 (0.75) | EPHX2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL22453465 | 0.81 | ALDH1A1 (0.50) | EPHX2ALDH1A1LMNACA1CA2 | |
| SCHEMBL22453165 | 0.79 | ALDH1A1 (0.79) | EPHX2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL399431 | 0.78 | ALDH1A1 (1.00) | EPHX2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL540915 | 0.78 | CA1 (0.85) | ALDH1A1CA1CA2CA9HTT | |
| SCHEMBL11793140 | 0.78 | CA1 (0.85) | ALDH1A1CA1CA2CA9HTT | |
| SCHEMBL28695220 | 0.78 | EPHX2 (0.43) | EPHX2ALDH1A1LMNACA1CA2 | |
| Hydrochloric Acid SCHEMBL1983434 | 0.77 | LMNA (0.96) | EPHX2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL22453449 | 0.75 | HIF1A (0.51) | EPHX2ALDH1A1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119490431-A | Novel small molecule inhibitors of TEAD transcription factors | 总医院公司 | 2025-02-21 | — | — | CN | disclosed |
| CN-113811300-B | Novel small molecule inhibitors of TEAD transcription factors | 总医院公司 | 2024-10-29 | — | — | CN | disclosed |
| EP-3937943-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | The General Hospital Corporation (US) | 2022-01-19 | — | — | EP | disclosed |
| CN-113811300-A | Novel small molecule inhibitors of TEAD transcription factor | 总医院公司 | 2021-12-17 | — | — | CN | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |