Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453463 | 0.84 | CRHBP (0.39) | ALDH1A1EPHX2CRHBPCRHR2APP | |
| SCHEMBL22452629 | 0.83 | NPC1 (0.59) | ALDH1A1LMNAEPHX2PGR | |
| SCHEMBL22445211 | 0.81 | EPHX2 (0.62) | ALDH1A1LMNAEPHX2CA1CA2 | |
| SCHEMBL22452725 | 0.79 | MEN1 (0.46) | ALDH1A1LMNAKDM4E | |
| SCHEMBL31168054 | 0.78 | ALDH1A1 (0.57) | ALDH1A1LMNAEPHX2APPKDM4E | |
| SCHEMBL22452681 | 0.78 | ALDH1A1 (0.57) | ALDH1A1LMNAEPHX2APPKDM4E | |
| SCHEMBL22452983 | 0.77 | MEN1 (0.48) | ALDH1A1LMNAKDM4E | |
| SCHEMBL4650462 | 0.74 | SERPINE1 (0.66) | — | |
| SCHEMBL1969932 | 0.72 | CA1 (0.50) | LMNACRHBPCRHR2APPCA1 | |
| SCHEMBL22452861 | 0.72 | ALDH1A1 (0.48) | ALDH1A1LMNAEPHX2P2RX7PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |