Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.54 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | GART | P22102 | 3/20 | 0.48 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.48 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.48 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.48 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246121 | 0.95 | CA12 (0.56) | CA12CA1CA9MMP12TAS1R3 | |
| SCHEMBL2246912 | 0.91 | MMP12 (0.58) | CA12CA1CA9MMP12TAS1R3 | |
| SCHEMBL2244792 | 0.86 | CA2 (0.56) | CA1TAS1R3TAS1R1PLK1HRH3 | |
| SCHEMBL2251669 | 0.83 | MMP12 (0.61) | MMP12HPGDSPTPN1ADAMTS4ADAMTS5 | |
| SCHEMBL2246054 | 0.83 | MMP12 (0.76) | CA12CA1CA9MMP12HPGDS | |
| SCHEMBL2245321 | 0.83 | MMP12 (0.76) | CA12CA1CA9MMP12HPGDS | |
| SCHEMBL3581707 | 0.82 | KLKB1 (0.59) | MMP12ADAMTS4ADAMTS5NPC1RAB9A | |
| SCHEMBL2249688 | 0.82 | MMP12 (0.61) | CA12CA1CA9MMP12TAS1R3 | |
| SCHEMBL2246124 | 0.82 | CA2 (0.56) | CA1TAS1R3TAS1R1HRH3GART | |
| SCHEMBL2246545 | 0.81 | MMP12 (0.61) | CA12CA1CA9MMP12HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |