Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.61 |
| ▸ | CA1 | P00915 | 3/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | HPGDS | O60760 | 3/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622966 | 0.88 | MMP12 (0.63) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2246054 | 0.88 | MMP12 (0.76) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2245321 | 0.88 | MMP12 (0.76) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL403968 | 0.86 | ADAMTS5 (0.58) | MMP12CA1CA12CA9ADAMTS5 | |
| SCHEMBL2245606 | 0.85 | MMP12 (0.65) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2249692 | 0.85 | CA2 (0.62) | CA1CA12CA9MMP2TAS1R3 | |
| SCHEMBL2246912 | 0.84 | MMP12 (0.58) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL27540278 | 0.84 | TAS1R3 (0.68) | CA1CA12CA9TAS1R3TAS1R1 | |
| SCHEMBL2246505 | 0.84 | MMP12 (0.64) | MMP12CA1CA12CA9HPGDS | |
| SCHEMBL2249740 | 0.83 | MMP12 (0.66) | MMP12CA1CA12CA9HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |