Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | BMP4 | P12644 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2319946 | 0.77 | ALOX5AP (0.35) | HSD17B10ALDH1A1HPGDKDM4ERAB9A | |
| SCHEMBL2258295 | 0.75 | HTR6 (0.41) | ALDH1A1HPGDKDM4E | |
| SCHEMBL2314828 | 0.74 | THRB (0.32) | IRAK4 | |
| SCHEMBL2249258 | 0.74 | THRB (0.37) | ALDH1A1HPGDKDM4E | |
| SCHEMBL3468681 | 0.74 | HTR6 (0.41) | SMPD3 | |
| SCHEMBL2359117 | 0.74 | KDM4E (0.34) | ALDH1A1LMNAKDM4EHTTNCOA1 | |
| SCHEMBL17697728 | 0.73 | SMPD3 (0.51) | SMPD3AXLNLRP3CDK2HSD17B10 | |
| SCHEMBL1243349 | 0.73 | SMPD3 (0.51) | SMPD3AXLCDK2HSD17B10ALDH1A1 | |
| SCHEMBL2317612 | 0.72 | HTR6 (0.58) | — | |
| SCHEMBL2322469 | 0.72 | THRB (0.34) | HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2248815-B1 | 3-SULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | AVINEURO PHARMACEUTICALS INC (US) | 2014-09-24 | — | — | EP | claimed |
| US-8618114-B2 | Substituted 3-arylsulfonyl-pyrazolo[1,5-A]pyrimidines, serotonin 5-HT6 receptor antagonists and methods for the production and use thereof | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2013-12-31 | — | — | US | claimed |
| US-8552005-B2 | (EN) 3-sulfonyl-pyrazolo[1,5-a] pyrimidines / antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof | Avincuro Pharmaceuticals, Inc. (US) | 2013-10-08 | — | — | US | claimed |
| EP-2351756-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | Ivashchenko, Andrey Alexandrovich (RU) | 2011-08-03 | — | — | EP | claimed |
| US-20110178078-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | IVASHCHENKO ANDREY ALEXANDROVICH | 2011-07-21 | — | — | US | claimed |
| US-20100331347-A1 | (EN) 3-SULFONYL-PYRAZOLO[1,5-A] PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | AVINEURO PHARMACEUTICALS, INC. | 2010-12-30 | — | — | US | claimed |
| EP-2248815-A2 | 3-SULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | Alla Chem, LLC. (US) | 2010-11-10 | — | — | EP | claimed |
| EP-3020719-B1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF AND METHODS FOR THE PRODUCTION AND USE THEREOF | ALLA CHEM LLC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-3020719-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOFAND METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-05-18 | — | — | EP | disclosed |
| EP-3020719-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOFAND METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-05-18 | — | — | EP | disclosed |
| EP-2248816-B1 | 2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO[1,5-A]PYRIMIDINES AS ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | ALLA CHEM LLC (US) | 2014-10-22 | — | — | EP | disclosed |
| EP-2248815-B1 | 3-SULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | AVINEURO PHARMACEUTICALS INC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-8629154-B2 | Substituted cycloalcano[e and d] pyrazolo [1,5-a]pyrimidines/antagonists of serotonin 5-HT6 receptors and methods for production and the use thereof | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2014-01-14 | — | — | US | disclosed |
| US-20100331347-A1 | (EN) 3-SULFONYL-PYRAZOLO[1,5-A] PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | AVINEURO PHARMACEUTICALS, INC. | 2010-12-30 | — | — | US | disclosed |
| US-20100292256-A1 | (EN) 2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO [1,5-A]PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | IVASHCHENKO ANDREY ALEXANDROVICH | 2010-11-18 | — | — | US | disclosed |
| EP-2248815-A2 | 3-SULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | Alla Chem, LLC. (US) | 2010-11-10 | — | — | EP | disclosed |
| EP-2248815-A2 | 3-SULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | Alla Chem, LLC. (US) | 2010-11-10 | — | — | EP | disclosed |
| EP-2248816-A2 | 2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR ] PYRAZOLO [1,5-A] PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | Alla Chem, LLC. (US) | 2010-11-10 | — | — | EP | disclosed |
| EP-2248814-A2 | SUBSTITUTED CYCLOALCANO[e AND d] PYRAZOLO [1,5-a] PYRIMIDINES/ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS AND METHODS FOR PRODUCTION AND THE USE THEREOF | Alla Chem, LLC. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2010041983-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ, ЛЛС (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292256-A1 | (EN) 2-ALKYLAMINO-3-ARYLSULFONYL-CYCLOALCANO [e OR d] PYRAZOLO [1,5-A]PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | HTR6, HTR1A, HTR3C | SMPD3 1632/4885AXL 839/4885NLRP3 2017/4885 |
| US-20100331347-A1 | (EN) 3-SULFONYL-PYRAZOLO[1,5-A] PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, METHODS FOR THE PRODUCTION AND THE USE THEREOF | HTR6, HTR1A, HTR3A | SMPD3 1636/4885AXL 890/4885NLRP3 858/4885 |
| US-20110178078-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | HTR6, HTR1A, HTR3A | SMPD3 2186/4885AXL 869/4885NLRP3 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.