Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453446 | 0.90 | NPC1 (0.44) | PGRNPC1MAPTLMNAHTT | |
| SCHEMBL22453033 | 0.90 | PGR (0.40) | PGRNPC1LMNAHTTSIRT2 | |
| SCHEMBL22452982 | 0.84 | CYP2C9 (0.48) | PGRNPC1MAPTLMNAHIF1A | |
| SCHEMBL22452808 | 0.84 | CYP2C9 (0.48) | PGRNPC1MAPTLMNAHIF1A | |
| SCHEMBL22452799 | 0.83 | EPHX2 (0.53) | PGRNPC1MAPTLMNAHIF1A | |
| SCHEMBL22452709 | 0.80 | LTC4S (0.40) | PGRNPC1MAPTLMNAHTT | |
| SCHEMBL22453689 | 0.80 | CYP2C9 (0.44) | PGRNPC1MAPTLMNAHIF1A | |
| SCHEMBL22453454 | 0.79 | SIRT2 (0.56) | PGRNPC1MAPTLMNAHTT | |
| SCHEMBL22452708 | 0.78 | EPHX2 (0.41) | NPC1GAAHIF1AEPAS1MEN1 | |
| SCHEMBL22453425 | 0.77 | HIF1A (0.43) | NPC1MAPTLMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |