Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452808 | 0.90 | CYP2C9 (0.48) | EPHX2NPC1CA1CA2CA9 | |
| SCHEMBL22452982 | 0.90 | CYP2C9 (0.48) | EPHX2NPC1CA1CA2CA9 | |
| SCHEMBL22452997 | 0.88 | EPHX2 (0.40) | EPHX2NPC1LMNAKDM4EP2RX7 | |
| SCHEMBL22453446 | 0.86 | NPC1 (0.44) | EPHX2NPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL22453689 | 0.86 | CYP2C9 (0.44) | EPHX2NPC1CA1CA2CA9 | |
| SCHEMBL22452656 | 0.85 | EPHX2 (0.47) | EPHX2NPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL22452708 | 0.84 | EPHX2 (0.41) | EPHX2NPC1CA1CA2CA9 | |
| SCHEMBL22452481 | 0.83 | PGR (0.48) | EPHX2NPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL22453312 | 0.82 | SERPINE1 (0.43) | EPHX2NPC1CA1CA2LMNA | |
| SCHEMBL22452496 | 0.78 | EPHX2 (0.41) | EPHX2NPC1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |