Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | PNLIP | P16233 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MDH1 | P40925 | 1/20 | 0.35 |
| ▸ | MDH2 | P40926 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453416 | 0.88 | HIF1A (0.42) | HIF1AEPAS1CYP1A2MAPTSLC2A1 | |
| SCHEMBL22452478 | 0.88 | HIF1A (0.40) | HIF1AEPAS1P2RX3PNLIP | |
| SCHEMBL22453603 | 0.84 | HIF1A (0.43) | HIF1AEPAS1CYP1A2MAPT | |
| SCHEMBL22452656 | 0.82 | EPHX2 (0.47) | HIF1AEPAS1CYP1A2MAPT | |
| SCHEMBL22453425 | 0.80 | HIF1A (0.43) | HIF1AEPAS1CYP1A2MAPTSLC2A1 | |
| SCHEMBL22452900 | 0.80 | HIF1A (0.38) | HIF1AEPAS1CYP1A2MAPTMDH1 | |
| SCHEMBL22453116 | 0.79 | HIF1A (0.47) | HIF1AEPAS1CYP1A2MAPTSLC2A1 | |
| SCHEMBL22453031 | 0.79 | PNLIP (0.37) | HIF1AP2RX3PNLIP | |
| SCHEMBL22453173 | 0.78 | HSP90AA1 (0.45) | HIF1ACYP1A2MAPT | |
| SCHEMBL22453205 | 0.76 | MAPT (0.46) | HIF1AEPAS1MAPTPNLIPMDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |