Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452496 | 0.86 | EPHX2 (0.41) | MAPTEPHX2MEN1KMT2ANPC1 | |
| SCHEMBL22452656 | 0.82 | EPHX2 (0.47) | CYP1A2MAPTEPHX2NPC1SMN1; SMN2 | |
| SCHEMBL22453425 | 0.80 | HIF1A (0.43) | CYP1A2MAPTSLC2A1MEN1KMT2A | |
| SCHEMBL22453116 | 0.80 | HIF1A (0.47) | CYP1A2MAPTSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL22453295 | 0.79 | PGR (0.44) | EPHX2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL22453173 | 0.78 | HSP90AA1 (0.45) | CYP1A2MAPTEPHX2MEN1KMT2A | |
| SCHEMBL22453416 | 0.76 | HIF1A (0.42) | CYP1A2MAPTSLC2A1MEN1KMT2A | |
| SCHEMBL28546720 | 0.74 | CYP1A2 (0.64) | CYP1A2MAPTSLC2A1MEN1KMT2A | |
| SCHEMBL22453534 | 0.73 | CYP1A2 (0.59) | CYP1A2MAPTSLC2A1MEN1KMT2A | |
| SCHEMBL22452559 | 0.73 | CNR2 (0.43) | CYP1A2MAPTSLC2A1EPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |