Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453295 | 0.91 | PGR (0.44) | EPHX2KDM4ELMNANPC1PGR | |
| SCHEMBL22453333 | 0.86 | CYP1A2 (0.43) | EPHX2KDM4ENPC1TDP1ALOX15 | |
| SCHEMBL22453671 | 0.82 | PGR (0.43) | KDM4ELMNANPC1PGRTDP1 | |
| SCHEMBL22452799 | 0.78 | EPHX2 (0.53) | EPHX2KDM4ELMNANPC1PGR | |
| SCHEMBL22453446 | 0.78 | NPC1 (0.44) | EPHX2KDM4ELMNANPC1PGR | |
| SCHEMBL22452805 | 0.77 | FABP4 (0.47) | EPHX2LMNAPGRTDP1ALOX15 | |
| SCHEMBL22452808 | 0.76 | CYP2C9 (0.48) | EPHX2KDM4ELMNANPC1PGR | |
| SCHEMBL22452982 | 0.76 | CYP2C9 (0.48) | EPHX2KDM4ELMNANPC1PGR | |
| SCHEMBL22453506 | 0.72 | LMNA (0.47) | EPHX2LMNANPC1PGRMAPT | |
| SCHEMBL22453686 | 0.71 | NPC1 (0.67) | EPHX2LMNANPC1PGRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |