Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ATF1 | P18846 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | MDH1 | P40925 | 1/20 | 0.33 |
| ▸ | MDH2 | P40926 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453603 | 0.92 | HIF1A (0.43) | HIF1ACYP1A2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL22453416 | 0.91 | HIF1A (0.42) | HIF1ACYP1A2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL22452779 | 0.88 | SERPINE1 (0.39) | SMN1; SMN2EPHX2 | |
| SCHEMBL22453715 | 0.82 | GAA (0.38) | CYP1A2MAPTTP53CACNA1BAPBA1 | |
| SCHEMBL22453334 | 0.80 | HIF1A (0.43) | HIF1ACYP1A2MAPTEPAS1MDH1 | |
| SCHEMBL22452985 | 0.79 | SERPINE1 (0.43) | HIF1ASMN1; SMN2ALDH1A1EPHX2KDM4E | |
| SCHEMBL22453312 | 0.78 | SERPINE1 (0.43) | HIF1ASMN1; SMN2ALDH1A1EPHX2KDM4E | |
| SCHEMBL22452617 | 0.78 | TAS2R14 (0.44) | HIF1ACYP1A2SMN1; SMN2MAPTEPHX2 | |
| SCHEMBL22452656 | 0.76 | EPHX2 (0.47) | HIF1ACYP1A2SMN1; SMN2MAPTTP53 | |
| SCHEMBL22453545 | 0.76 | HPGD (0.52) | HIF1ASMN1; SMN2MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |