Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNLIP | P16233 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452478 | 0.90 | HIF1A (0.40) | PNLIPSCN9AEPHX2P2RX3PARP1 | |
| SCHEMBL22452975 | 0.87 | AURKA (0.36) | HIF1A | |
| SCHEMBL22452997 | 0.80 | EPHX2 (0.40) | EPHX2 | |
| SCHEMBL22453334 | 0.79 | HIF1A (0.43) | PNLIPP2RX3HIF1A | |
| SCHEMBL22452709 | 0.77 | LTC4S (0.40) | — | |
| SCHEMBL22453729 | 0.77 | TTK (0.34) | — | |
| SCHEMBL22453312 | 0.76 | SERPINE1 (0.43) | EPHX2HIF1A | |
| SCHEMBL22453533 | 0.76 | EPHX2 (0.40) | EPHX2 | |
| SCHEMBL22453033 | 0.74 | PGR (0.40) | EPHX2 | |
| SCHEMBL22453246 | 0.74 | AURKA (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |