Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453322 | 0.89 | POLB (0.44) | P2RX7SERPINE1EPHX2PTK2MAPK1 | |
| SCHEMBL22453029 | 0.89 | EPHX2 (0.48) | P2RX7KMT2AGPR55EPHX2PTK2 | |
| SCHEMBL22452486 | 0.86 | HIF1A (0.50) | P2RX7KMT2ASERPINE1EPHX2NPC1 | |
| SCHEMBL22453525 | 0.85 | MAPT (0.50) | KMT2AGPR55SERPINE1EPHX2NPC1 | |
| SCHEMBL22452762 | 0.85 | SIRT2 (0.46) | P2RX7SERPINE1EPHX2NPC1HIF1A | |
| SCHEMBL22453612 | 0.84 | P2RX7 (0.43) | P2RX7KMT2AGPR55SERPINE1EPHX2 | |
| SCHEMBL31555349 | 0.80 | SERPINE1 (0.51) | KMT2ASERPINE1EPHX2NPC1HIF1A | |
| SCHEMBL22453520 | 0.80 | SERPINE1 (0.51) | KMT2ASERPINE1EPHX2NPC1HIF1A | |
| SCHEMBL22452789 | 0.80 | SERPINE1 (0.61) | KMT2ASERPINE1EPHX2NPC1HIF1A | |
| SCHEMBL22452715 | 0.80 | SERPINE1 (0.64) | KMT2ASERPINE1EPHX2NPC1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |