Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452529 | 0.89 | DHODH (0.41) | P2RX7NPC1SERPINE1KMT2AAXL | |
| SCHEMBL22452486 | 0.87 | HIF1A (0.50) | P2RX7EPHX2NPC1SERPINE1KMT2A | |
| SCHEMBL22453525 | 0.87 | MAPT (0.50) | EPHX2NPC1SERPINE1KMT2AGPR55 | |
| SCHEMBL22453322 | 0.87 | POLB (0.44) | P2RX7EPHX2NPC1SERPINE1ALK | |
| SCHEMBL22452762 | 0.86 | SIRT2 (0.46) | P2RX7EPHX2NPC1SERPINE1HIF1A | |
| SCHEMBL22453611 | 0.84 | P2RX7 (0.43) | P2RX7EPHX2NPC1SERPINE1KMT2A | |
| SCHEMBL22452750 | 0.82 | NPC1 (0.38) | P2RX7EPHX2NPC1SERPINE1KMT2A | |
| SCHEMBL22453520 | 0.80 | SERPINE1 (0.51) | EPHX2NPC1SERPINE1KMT2AHIF1A | |
| SCHEMBL31555349 | 0.80 | SERPINE1 (0.51) | EPHX2NPC1SERPINE1KMT2AHIF1A | |
| SCHEMBL22453415 | 0.78 | SERPINE1 (0.53) | P2RX7EPHX2NPC1SERPINE1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |