Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453336 | 0.88 | PGR (0.40) | PGRKMT2AEPHX2MEN1POLB | |
| SCHEMBL22452667 | 0.80 | HIF1A (0.44) | PGRKMT2ALMNAMEN1NPSR1 | |
| SCHEMBL22453481 | 0.79 | PGR (0.46) | PGRKMT2ALMNANPSR1HTT | |
| SCHEMBL22452673 | 0.78 | PGR (0.50) | PGRKMT2ALMNANPSR1HTT | |
| SCHEMBL22453480 | 0.77 | MAPT (0.52) | PGRKMT2AEPHX2MEN1GAA | |
| SCHEMBL22453740 | 0.76 | NPSR1 (0.42) | PGRKMT2ALMNAMEN1GAA | |
| SCHEMBL22452670 | 0.76 | LMNA (0.41) | PGRKMT2ALMNAMEN1GAA | |
| SCHEMBL22452675 | 0.75 | MDH1 (0.39) | PGRKMT2AEPHX2LMNAMEN1 | |
| SCHEMBL22452516 | 0.73 | HIF1A (0.47) | PGRKMT2AEPHX2LMNAMEN1 | |
| SCHEMBL4956421 | 0.72 | KMT2A (0.59) | KMT2ALMNAGAANPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |