Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.41 |
| ▸ | SMO | Q99835 | 5/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MDH1 | P40925 | 1/20 | 0.38 |
| ▸ | MDH2 | P40926 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453410 | 0.87 | CNR2 (0.46) | SMOLMNAMAPTMDH1MDH2 | |
| SCHEMBL22452675 | 0.87 | MDH1 (0.39) | EPHX2LMNAHTTNPSR1RCE1 | |
| SCHEMBL22452674 | 0.81 | CNR2 (0.42) | LMNAHTTNPSR1RCE1MAPT | |
| SCHEMBL22452612 | 0.79 | MAPT (0.46) | TAS2R14EPHX2LMNAMAPTALOX15 | |
| SCHEMBL22452503 | 0.79 | MAPT (0.58) | EPHX2LMNAHTTNPSR1RCE1 | |
| SCHEMBL22452501 | 0.79 | MAPT (0.55) | EPHX2NPSR1MAPTALOX15MDH1 | |
| SCHEMBL22453252 | 0.78 | HIF1A (0.39) | EPHX2LMNAHTTNPSR1RCE1 | |
| SCHEMBL22453203 | 0.77 | CNR2 (0.54) | EPHX2LMNAHTTNPSR1RCE1 | |
| SCHEMBL22452810 | 0.76 | HIF1A (0.53) | TAS2R14EPHX2LMNAHTTNPSR1 | |
| SCHEMBL22452652 | 0.76 | EPHX2 (0.61) | EPHX2LMNAMAPTALOX15MDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |