Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453418 | 0.87 | TAS2R14 (0.41) | SMOMAPTHIF1ALMNAEPAS1 | |
| SCHEMBL22452674 | 0.87 | CNR2 (0.42) | CNR2MAPTHIF1ALMNAEPAS1 | |
| SCHEMBL22452675 | 0.84 | MDH1 (0.39) | CNR2MAPTHIF1ALMNAEPAS1 | |
| SCHEMBL22452620 | 0.81 | CNR2 (0.51) | CNR2MAPTHIF1ALMNAPOLB | |
| SCHEMBL22453725 | 0.80 | CNR2 (0.56) | CNR2MAPTHIF1ALMNAEPAS1 | |
| SCHEMBL22453036 | 0.79 | HIF1A (0.36) | SMOMAPTHIF1ALMNAEPAS1 | |
| SCHEMBL22453152 | 0.78 | CNR2 (0.47) | CNR2MAPTHIF1ALMNAEPAS1 | |
| SCHEMBL22453427 | 0.77 | CNR2 (0.57) | CNR2MAPTHIF1AEPAS1DHODH | |
| SCHEMBL22452622 | 0.77 | CNR2 (0.60) | CNR2MAPTHIF1APOLBEPAS1 | |
| SCHEMBL22453108 | 0.77 | CNR2 (0.59) | CNR2MAPTHIF1ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |