Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452630 | 0.86 | LMNA (0.45) | KMT2AALDH1A1TDP1EPHX2 | |
| SCHEMBL22453465 | 0.84 | ALDH1A1 (0.50) | CRHBPCRHR2HSD17B2APPHTR6 | |
| SCHEMBL22452710 | 0.81 | MEN1 (0.44) | CRHBPCRHR2KMT2AMEN1ALDH1A1 | |
| SCHEMBL22453477 | 0.80 | LMNA (0.42) | CRHBPCRHR2KMT2AMEN1ALDH1A1 | |
| SCHEMBL22453130 | 0.76 | EPHX2 (0.39) | KMT2AMEN1TSHRALDH1A1CYP3A4 | |
| SCHEMBL22453123 | 0.75 | EPHX2 (0.43) | HDAC8HDAC6CA1CA2CA9 | |
| SCHEMBL22453742 | 0.75 | GRIN2D (0.40) | HDAC1HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL22453128 | 0.74 | LMNA (0.56) | KMT2AMEN1ALDH1A1EPHX2 | |
| SCHEMBL22453159 | 0.73 | PDE7A (0.43) | KMT2AMEN1ALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL22453702 | 0.70 | PTPN11 (0.45) | CA1CA2KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |