Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452598 | 0.86 | MEN1 (0.43) | MEN1POLBGAAKMT2ASLC6A3 | |
| SCHEMBL22453196 | 0.83 | KMT2A (0.45) | MEN1POLBGAAKMT2ASLC6A3 | |
| SCHEMBL22453700 | 0.75 | BACE1 (0.38) | MEN1GAAKMT2A | |
| SCHEMBL900460 | 0.71 | MEN1 (0.66) | MEN1POLBGAAKMT2ASLC6A3 | |
| SCHEMBL21409728 | 0.70 | MEN1 (0.56) | MEN1POLBGAAKMT2ASLC6A3 | |
| SCHEMBL29294171 | 0.69 | MEN1 (0.57) | MEN1POLBGAAKMT2ASLC6A3 | |
| SCHEMBL23339624 | 0.66 | MEN1 (0.49) | MEN1POLBGAAKMT2ASLC6A3 | |
| SCHEMBL22453357 | 0.66 | KIF11 (0.41) | GAASLC6A3SLC6A4SLC6A2 | |
| SCHEMBL22452606 | 0.66 | ALDH1A1 (0.38) | — | |
| SCHEMBL13086071 | 0.65 | GAA (0.73) | MEN1POLBGAAKMT2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |