Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.37 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453295 | 0.92 | PGR (0.44) | PGRKDM4ELMNACYP2C9DNMT1 | |
| SCHEMBL22452808 | 0.87 | CYP2C9 (0.48) | PGRKDM4ELMNACYP2C9NPC1 | |
| SCHEMBL22452982 | 0.87 | CYP2C9 (0.48) | PGRKDM4ELMNACYP2C9NPC1 | |
| SCHEMBL22453689 | 0.85 | CYP2C9 (0.44) | PGRKDM4ELMNACYP2C9DNMT1 | |
| SCHEMBL22452496 | 0.82 | EPHX2 (0.41) | PGRKDM4ELMNANPC1POLB | |
| SCHEMBL22453229 | 0.80 | SIRT2 (0.50) | PGRNPC1POLBRAB9ASERPINE1 | |
| SCHEMBL22452799 | 0.78 | EPHX2 (0.53) | PGRKDM4ELMNANPC1CA1 | |
| SCHEMBL22453116 | 0.76 | HIF1A (0.47) | PGRCYP2C9NPC1POLBRAB9A | |
| SCHEMBL22452481 | 0.74 | PGR (0.48) | PGRKDM4ELMNACYP2C9NPC1 | |
| SCHEMBL22453446 | 0.73 | NPC1 (0.44) | PGRKDM4ELMNACYP2C9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |