SCHEMBL22461493

SCHEMBL22461493

CC(=O)Nc1ccc(C(=O)Nc2ccc(C(=O)Nc3ccc(-c4c5nc(c(-c6cc[n+](C)cc6)c6ccc([nH]6)c(-c6cc[n+](C)cc6)c6nc(c(-c7cc[n+](C)cc7)c7ccc4[nH]7)C=C6)C=C5)cc3)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TERT O14746 5/20 0.58
▸ TOP1 P11387 3/20 0.51
▸ CYCS P99999 4/20 0.50
▸ ABCG2 Q9UNQ0 1/20 0.44
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ CACNA1B Q00975 1/20 0.43
▸ APBA1 Q02410 1/20 0.43
▸ AGER Q15109 1/20 0.42
▸ ENPP2 Q13822 1/20 0.41
▸ HPSE Q9Y251 1/20 0.41
▸ POLB P06746 1/20 0.39
▸ MCL1 Q07820 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22461492 1.00 TERT (0.58) TERTTOP1CYCSABCG2MEN1
SCHEMBL22461491 1.00 TERT (0.58) TERTTOP1CYCSABCG2MEN1
SCHEMBL8994447 0.85 TOP1 (0.60) TERTTOP1CYCSABCG2MEN1
SCHEMBL9910535 0.81 ABCG2 (0.55) TERTTOP1CYCSABCG2MEN1
SCHEMBL14077524 0.79 ABCG2 (0.54) TERTTOP1CYCSABCG2MEN1
SCHEMBL7241022 0.79 TOP1 (0.58) TERTTOP1CYCSABCG2MEN1
SCHEMBL1974241 0.79 TOP1 (0.68) TERTTOP1CYCSABCG2MEN1
SCHEMBL15580416 0.79 TERT (0.65) TERTTOP1CYCSABCG2KMT2A
Tmpyp4 SCHEMBL265519 0.77 TERT (0.97) TERTTOP1CYCSABCG2ENPP2
Tmpyp4 SCHEMBL29369473 0.76 TERT (1.00) TERTTOP1CYCSABCG2ENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200298194-A1 ARAMID AMPHIPHILE SELF-ASSEMBLED NANOSTRUCTURES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2020-09-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200298194-A1 ARAMID AMPHIPHILE SELF-ASSEMBLED NANOSTRUCTURES ANXA6, ANXA1, ANXA11 TERT 888/4885TOP1 917/4885CYCS 2268/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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