Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.64 |
| ▸ | MMP8 | P22894 | 1/20 | 0.64 |
| ▸ | MMP12 | P39900 | 1/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | SUCNR1 | Q9BXA5 | 5/20 | 0.44 |
| ▸ | BMP1 | P13497 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247767 | 0.94 | ADAMTS5 (0.60) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL3577956 | 0.82 | KDM4E (0.55) | MMP2SUCNR1BMP1KDM4EMAPT | |
| SCHEMBL2242407 | 0.82 | ADAMTS5 (0.86) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2245862 | 0.82 | ADAMTS5 (0.86) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2247314 | 0.80 | ADAMTS5 (0.81) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2247800 | 0.79 | HPGDS (0.52) | MMP2MMP8MMP12SUCNR1S1PR4 | |
| SCHEMBL13196748 | 0.79 | ADAMTS5 (0.83) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2244925 | 0.79 | ADAMTS5 (0.79) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL2245160 | 0.79 | ADAMTS5 (0.79) | ADAMTS5MMP2MMP8MMP12ADAMTS4 | |
| SCHEMBL3581142 | 0.78 | MMP2 (0.47) | ADAMTS5MMP2MMP8MMP12KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | ADAMTS5 1/4885MMP2 49/4885MMP8 70/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | ADAMTS5 1/4885MMP2 49/4885MMP8 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.