Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 3/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487104 | 1.00 | MAOA (0.41) | MAOAMAOBPARP1TDP1SMN1; SMN2 | |
| SCHEMBL5541188 | 0.81 | CA1 (0.35) | — | |
| SCHEMBL5913497 | 0.81 | MAOA (0.33) | MAOAMAOBPARP1 | |
| SCHEMBL11017349 | 0.74 | — | — | |
| SCHEMBL3258105 | 0.71 | GRM2 (0.38) | — | |
| SCHEMBL10901572 | 0.70 | — | — | |
| SCHEMBL5913501 | 0.70 | POLB (0.33) | — | |
| SCHEMBL20482181 | 0.69 | BRD4 (0.41) | MAOAMAOBTDP1SMN1; SMN2BRD4 | |
| SCHEMBL2283159 | 0.68 | TDP1 (0.33) | MAOAMAOBPARP1TDP1SMN1; SMN2 | |
| SCHEMBL8471197 | 0.67 | BRD4 (0.50) | MAOAMAOBPARP1TDP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350028-B2 | 2-aminoquinolines | HOFMANN-LA ROCHE INC. (US) | 2013-01-08 | — | — | US | claimed |
| US-7989628-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | claimed |
| US-20090233927-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | US | claimed |
| US-20090227628-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-10 | — | — | US | claimed |
| US-4122204-A | MITICIDES, INSECTICIDES | UNION CARBIDE CORPORATION (US) | 1978-10-24 | — | — | US | claimed |
| US-20140162906-A1 | Pesticide Biomarker | NAGY JON OWEN (US) | 2014-06-12 | — | — | US | disclosed |
| US-8350028-B2 | 2-aminoquinolines | HOFMANN-LA ROCHE INC. (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2262774-B1 | 2-aminoquinolines as 5-HT5A receptor antagonists, their manufacture and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |
| US-7989628-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| EP-2262774-A2 | 2-AMINOQUINOLINES | F. Hoffmann-La Roche AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| EP-2254666-A1 | 2-AMINOQUINOLINES AS 5-HT5A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-12-01 | — | — | EP | disclosed |
| US-20100041077-A1 | PESTICIDE BIOMARKER | ATERIS TECHNOLOGIES, LLC | 2010-02-18 | — | — | US | disclosed |
| US-20090227628-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-10 | — | — | US | disclosed |
| EP-0906014-B1 | Shaped bodies which release agrochemicals | BAYER AG (DE) | 2002-03-27 | — | — | EP | disclosed |
| EP-0906014-A1 | SHAPED BODIES WHICH RELEASE AGROCHEMICAL ACTIVE SUBSTANCES | BAYER AG (DE) | 1999-04-07 | — | — | EP | disclosed |
| EP-0861024-A1 | POLYSACCHARIDE ETHER ESTERS WHICH RELEASE ACTIVE INGREDIENTS | BAYER AG (DE) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997046094-A1 | SHAPED BODIES WHICH RELEASE AGROCHEMICAL ACTIVE SUBSTANCES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-12-11 | — | — | WO | disclosed |
| WO-1997017847-A1 | POLYSACCHARIDE ETHER ESTERS WHICH RELEASE ACTIVE INGREDIENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-05-22 | — | — | WO | disclosed |
| US-4180672-A | 2-Organothio-2-cyclopentenones, organothio-cyclopentanes derived therefrom | TEIJIN LIMITED (JP) | 1979-12-25 | — | — | US | disclosed |
| US-4122204-A | MITICIDES, INSECTICIDES | UNION CARBIDE CORPORATION (US) | 1978-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233927-A1 | 2-AMINOQUINOLINES | HTR5A, HTR2C, HTR2B | MAOA 421/4885MAOB 238/4885PARP1 1017/4885 |
| US-20090227628-A1 | 2-AMINOQUINOLINES | HTR5A, HTR1A, HTR1E | MAOA 482/4885MAOB 377/4885PARP1 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.