Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | C3AR1 | Q16581 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380926 | 0.89 | LMNA (0.58) | TAS1R3TAS1R1ALDH1A1HPGDCA2 | |
| SCHEMBL9380922 | 0.89 | LMNA (0.58) | TAS1R3TAS1R1ALDH1A1HPGDCA2 | |
| SCHEMBL2248650 | 0.84 | LMNA (0.56) | TAS1R3TAS1R1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2247803 | 0.82 | C3AR1 (0.55) | CA2CA1KMT2AC3AR1 | |
| SCHEMBL13892828 | 0.81 | HPGD (0.72) | TAS1R3TAS1R1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2247341 | 0.78 | C3AR1 (0.53) | ALDH1A1CA2CA1NPSR1KMT2A | |
| SCHEMBL2245141 | 0.77 | C3AR1 (0.61) | ALDH1A1CA2CA1NPSR1KMT2A | |
| SCHEMBL13330083 | 0.77 | CA2 (0.66) | CA2CA1KMT2AC3AR1 | |
| SCHEMBL2244860 | 0.76 | CA2 (0.69) | CA2CA1KMT2AC3AR1 | |
| SCHEMBL2244829 | 0.76 | S1PR4 (0.48) | ALDH1A1HPGDCA2CA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |