SCHEMBL22490894

SCHEMBL22490894

O=C(NC[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O)c1cc(Cl)c(OCc2ccccc2)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 1/20 0.42
HK1 P19367 2/20 0.40
HK2 P52789 2/20 0.40
KDM4E B2RXH2 2/20 0.39
HPGD P15428 3/20 0.37
ALDH1A1 P00352 3/20 0.37
MEN1 O00255 2/20 0.37
MAPT P10636 2/20 0.37
RAB9A P51151 2/20 0.37
KMT2A Q03164 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
ABL1 P00519 1/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
RIN1 Q13671 1/20 0.37
DRD2 P14416 1/20 0.37
DRD3 P35462 1/20 0.37
PLAU P00749 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23488667 0.80 KDM4E (0.43) KDM4EHPGDALDH1A1MEN1MAPT
SCHEMBL23488501 0.79 CA1 (0.52) KDM4ELMNADRD2DRD3
SCHEMBL23488332 0.77 CA2 (0.54) HK1HK2
SCHEMBL23488670 0.77 CA2 (0.54) HK1HK2
SCHEMBL23488653 0.75 CA1 (0.42) MEN1KMT2AHRAS
SCHEMBL23488701 0.72 LGALS8 (0.50) KDM4EHPGDLMNA
SCHEMBL23488534 0.72 CA2 (0.50) HK1HK2KDM4E
SCHEMBL23488754 0.70 SLC6A5 (0.42) KDM4EMEN1KMT2A
SCHEMBL1457712 0.68 MEN1 (0.63) KDM4EHPGDMEN1RAB9AKMT2A
SCHEMBL23067512 0.68 KDM4E (0.66) KDM4EHPGDALDH1A1MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
EP-3717463-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2020-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 SLC5A2 10/4885HK1 300/4885HK2 356/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.