Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | GGH | Q92820 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.34 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904869 | 1.00 | FOLH1 (0.40) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL8878008 | 0.90 | TSHR (0.44) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL8878021 | 0.90 | TSHR (0.44) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL9114355 | 0.86 | GGH (0.50) | FOLH1GGHRIMKLANAALAD2 | |
| SCHEMBL20813494 | 0.83 | SLC1A1 (0.41) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL149082 | 0.82 | KMT2A (0.48) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL5023601 | 0.81 | NOD1 (0.46) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL2242496 | 0.81 | NOD1 (0.46) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL23355119 | 0.81 | GGT1 (0.44) | FOLH1KMT2AALOX15BLMPMP22 | |
| SCHEMBL23355118 | 0.81 | GGT1 (0.44) | FOLH1KMT2AALOX15BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |
| US-5698046-A | REDUCES SPOTTING AND FILMING ON TABLEWARE | THE PROCTER & GAMBLE COMAPNY (US) | 1997-12-16 | — | — | US | disclosed |
| WO-1995007340-A1 | BAR COMPOSITION WITH N-ALKOXY OR N-ARYLOXY POLYHYDROXY FATTY ACID AMIDE SURFACTANT | THE PROCTER & GAMBLE COMPANY (US) | 1995-03-16 | — | — | WO | disclosed |
| WO-1995007256-A1 | N-ALKOXY POLYHYDROXY FATTY ACID AMIDES AND SYNTHESIS THEREOF | THE PROCTER & GAMBLE COMPANY (US) | 1995-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | FOLH1 17/4885KMT2A 2364/4885ALOX15 2170/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | FOLH1 17/4885KMT2A 2364/4885ALOX15 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.