Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | GRM8 | O00222 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GRM6 | O15303 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22500876 | 1.00 | SLC6A4 (0.38) | SLC6A4CHRNB2CHRNA3CHRNA4CHRNB3 | |
| Hydrochloric Acid SCHEMBL22493932 | 0.98 | SLC6A4 (0.37) | SLC6A4CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL22493906 | 0.79 | GABRR1 (0.33) | SLC6A4GABRR1 | |
| SCHEMBL12473695 | 0.78 | — | — | |
| SCHEMBL301120 | 0.78 | — | — | |
| SCHEMBL1173556 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL11821301 | 0.76 | — | — | |
| Bromide SCHEMBL11824101 | 0.76 | — | — | |
| SCHEMBL22519005 | 0.74 | CHRNB2 (0.36) | SLC6A4CHRNB2CHRNA3CHRNA4CHRNB3 | |
| Hydrochloric Acid SCHEMBL31072095 | 0.67 | SLC6A4 (0.40) | SLC6A4GABRR1GRM4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078153-B2 | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase | NORTHWESTERN UNIVERSITY (US) | 2021-08-03 | — | — | US | disclosed |
| US-11078153-B2 | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase | NORTHWESTERN UNIVERSITY (US) | 2021-08-03 | — | — | US | disclosed |
| US-20200317606-A1 | 2-DIFLUORO SUBSTITUTED 4-AMINOCYCLOPENTANECARBOXYLIC ACIDS AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID AMINOTRANSFERASE AND HUMAN ORNITHINE AMINOTRANSFERASE | NORTHWESTERN UNIVERSITY (US) | 2020-10-08 | — | — | US | disclosed |
| WO-2020206234-A1 | 2-DIFLUORO SUBSTITUTED 4-AMINOCYCLOPENTANECARBOXYLIC ACIDS AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID AMINOTRANSFERASE AND HUMAN ORNITHINE AMINOTRANSFERASE | NORTHWESTERN UNIVERSITY (US) | 2020-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078153-B2 | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase | OAT, OTC, SLC6A13 | SLC6A4 226/4885CHRNB2 1529/4885CHRNA3 1881/4885 |
| US-20200317606-A1 | 2-DIFLUORO SUBSTITUTED 4-AMINOCYCLOPENTANECARBOXYLIC ACIDS AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID AMINOTRANSFERASE AND HUMAN ORNITHINE AMINOTRANSFERASE | OAT, OTC, SLC6A13 | SLC6A4 226/4885CHRNB2 1529/4885CHRNA3 1881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.